Phenytoin concentration in people with epilepsy: a comparative study in serum and saliva

In clinical practice, therapeutic drug monitoring (TDM) makes it possible to measure the concentration of drugs in serum or saliva, purpose which is reduce adverse effects and optimize pharmacological therapy. The objective was determine concentrations Phenytoin saliva people with epilepsy. Cross-sectional, descriptive study dynamic recruitment 30 epilepsy (n = 30; 17 men, 56.7% 13 women, 43.3%; mean age 33.9 ± 11.83 years). Serum samples were collected at trough levels from patients, who under phenytoin treatment for least three months. Drug assessed by Cloned Donor Enzyme Immunoassay method. found between 0.01 3.56 mg/L 0.09 36.60 mg/L. Pearson’s analysis showed an association estimated (R 2 0.7026; 95% CI 0.685-0.921), a significant statistical correlation (p < 0.05). Bland-Altman test broke concordance, difference two saliva/serum methods within confidence. It concluded that there concordance therefore, this technique can be useful phenytoin.